Inside human cells, biology has pulled off the ultimate packing job, figuring out how to fit six feet of DNA into a nucleus ...

New ultra-detailed imaging exposes the hidden structure and behavior of chromatin condensates — and hints at how their ...

This week in Science, Michael K. Rosen and 10 other members of a large collaboration at the Marine Biological Laboratory, the ...

A team of researchers led by HHMI Investigator Michael Rosen has captured the most detailed images yet of the molecules in synthetic chromatin condensates — droplet-like structures of compacted DNA.

The nuclei of most human cells contains the entire genome, which would have a length of about six feet if it was fully extended. So this DNA has to be carefully compacted in cells, while still ...

Heat shock (HS) initiates rapid, extensive, and evolutionarily conserved changes in transcription that are accompanied by chromatin decondensation and nucleosome loss at HS loci. Here we have employed ...

The establishment of de novo chromatin accessibility in lymphoid progenitors requires the “pioneering” function of transcription factor (TF) early B cell factor 1 (EBF1), which binds to naïve ...

Researchers discovered that stiff DNA segments inside nucleosomes physically block chromatin remodeling. The remodeling ...

Findings represent a detailed resource for future research that could lead to the development of new biomarkers and targeted therapeutics for T1D.