The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

With the rapid rise of next-generation sequencing (NGS), one of its technologies, RNA sequencing (RNA-Seq), has taken center stage for analyzing whole transcriptomes. Although RNA-Seq is still the new ...

Spatial RNA medicine combines transcriptomics and RNA therapeutics, mapping gene expression in tissues to enhance precision ...

Central nervous system tumors accounted for 30 of the 48 revised diagnoses. In 13 cases, RNA-seq reclassified ependymoma as glioma, astroblastoma, or paraganglioma. Seven low-grade gliomas were ...

Cas13 is capable of intrinsically targeting host RNA in mammalian cells through mechanisms that were not previously understood. Through transcript-specific mechanisms that are independent of the ...