There are only about 20,000 different genes in the human genome, yet our bodies are filled with an incredible diversity of cell types performing innumerable functions. The key to that diversity in ...

For many years, scientists have known about one of the most fundamental processes in biology, where cells use a DNA sequence to transcribe an RNA molecule, and use that to generate a protein. But ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

A new study captures RNA polymerase II in real time, revealing how it accelerates, pauses and shifts speed as it reads DNA.

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...