This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues ...

All cells need to sense and respond to their environment, to know when to activate genes, build proteins, and carry out their ...

In the fast-evolving field of medical science, a new artificial intelligence model may be about to change the way mRNA-based drugs and vaccines are designed. Developed through a collaboration between ...

N 6-methyladenosine (m 6 A) is the most extensive studied RNA modification across various species, and the important effect of m 6 A modification in immune system has been revealed in distinct ...

Messenger RNA (mRNA) is translated into proteins in the cytoplasm of cells. But rather than being a uniform “soup,” the cytoplasm is divided into multiple distinct compartments or regions. Each region ...

Genome-wide CRISPR knockout screens to identify cellular regulators of LNP-based mRNA vaccines. mRNAs encoding Green Fluorescent Protein (GFP) were in vitro transcribed (IVT) and delivered to knockout ...

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A pizza shop with 30 delivery people ought to be able to deliver a lot of pizzas—if their cars don't break down on the way. Likewise, genes that produce a lot of messenger RNA (mRNA) molecules can ...

The same groundbreaking technology that enabled rapid COVID-19 vaccine development is now poised to revolutionize medicine in ways that seemed impossible just a few years ago. Messenger RNA vaccines ...

Few medical advances in recent memory have sparked as much controversy as COVID-19 vaccines utilizing mRNA (messenger RNA). Currently, there are two such vaccines, from Pfizer-BioNTech and Moderna.