Inside every human cell, six feet of DNA folds into a nucleus that is only a few micrometers wide, yet still manages to ...

Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial ...

Understanding the dynamic behavior of DNA remains an important challenge to biophysics, in particular the folding and stretching of DNA is critical since protein-DNA interactions require that the ...

Research chemists have a found a class of synthetic molecules that could quite literally act as a key which could lock away sections of DNA into a closely wound coil preventing proteins from ...

Single-molecule real-time (SMRT) DNA sequencing 1 has opened many avenues in genomic interrogation 1,2,3. In SMRT sequencing, DNA strand replication by an individual DNA polymerase is optically ...